Recovery of spiked troponin I in four routine assays
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چکیده
منابع مشابه
Recovery of spiked troponin I in four routine assays
INTRODUCTION This study aimed to examine the recovery of spiked human cardiac troponin I (cTnI) results measured by four routine assays, and investigate possible interference from microclots. MATERIALS AND METHODS 457 consecutive samples with cTnI concentration below limit of quantitation (12 ng/L), declared by the Vitros TnI ES assay (reference assay), were measured on Beckman Coulter Accu T...
متن کاملDegradation of cardiac troponin I in serum complicates comparisons of cardiac troponin I assays.
BACKGROUND Up to a 20-fold variation in serum cardiac troponin I (cTnI) concentration may be observed for a given patient sample with different analytical methods. Because more limited variation is seen for control materials and for purified cTnI, we explored the possibility that cTnI was present in altered forms in serum. METHODS We used four recombinantly engineered cTnI fragments to study ...
متن کاملClinical performance of two highly sensitive cardiac troponin I assays.
BACKGROUND The aim of this study was to compare the clinical performance of 2 sensitive cTnI assays with 10% CV imprecision below the 99th percentile upper reference limit. METHODS We measured cardiac troponin and N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in a random sample of the Global Use of Strategies To Open Occluded Coronary Arteries (GUSTO) IV cohort (n = 1251...
متن کاملCardiac Troponin Assays
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متن کاملCounterpoint: Standardization of cardiac troponin I assays will not occur in my lifetime.
I have chosen to address the argument of why cardiac troponin I (cTnI) assays will likely never be standardized. It is not that I do not wish it would happen, but I think the scientific, evidence-based story I will present regarding this cardiac specific protein will speak for itself. As a means to present this argument, I would like to consider the following analogy. I am an avid trail runner....
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ژورنال
عنوان ژورنال: Biochemia Medica
سال: 2016
ISSN: 1846-7482
DOI: 10.11613/bm.2016.025